The Epidemiology of Nonsteroidal Anti-Inflammatory Drugs

Nonsteroidal anti-inflammatory drugs.

Non-steroidal anti-inflammatory drugs (NSAIDs) are usually defined as those agents that inhibit one or more reactions involved in the production of prostaglandins and thromboxanes, important mediators of the inflammatory process in many organs and tissues. They find use in horses in the supportive treatment of a variety of systemic states and painful musculoskeletal or soft tissue conditions. T...

Nonsteroidal Anti-Inflammatory Drugs and the Kidney

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the isoenzymes COX-1 and COX-2 of cyclooxygenase (COX). Renal side effects (e.g., kidney function, fluid and urinary electrolyte excretion) vary with the extent of COX-2-COX-1 selectivity and the administered dose of these compounds. While young healthy subjects will rarely experience adverse renal effects with the use of NSAIDs, elderly pa...

Nonsteroidal anti-inflammatory drugs and the heart.

Nonsteroidal anti-inflammatory drugs in orthopaedics.

It is important for orthopaedic surgeons to understand the role of prostaglandins in bone physiology and the mechanism of action of nonsteroidal anti-inflammatory drugs and their role in fracture healing, fusion, osteointegration, and aseptic loosening. Nonsteroidal anti-inflammatory drugs have benefits and risks in orthopaedic use, and their effects should be considered.

Nonsteroidal anti-inflammatory drugs: cyclooxygenase 2 inhibitors.

OBJECTIVES To analyze selective COX 2 inhibitor nonsteroidal anti-inflammatory drugs (NSAID) in terms of their mechanism of action, principal indications, posology and most common adverse effects. SOURCES MEDLINE and LILACS databases and Food and Drug Administration (FDA) and National Agency for Sanitary Vigilance (ANVISA - Agência Nacional de Vigilância Sanitária) websites. The most importan...